Reduction in development time
30%
0
Real-time thermocycler offering individually controlled wells
First to Market
0
Individually controlled wells for precise reaction control
96
0
Case Study
Delivering a First-to-Market Thermocycler with Real-Time DNA Amplification and Sequencing for Genetic Analysis
A genomics technology company had a concept for a novel real-time thermocycler that they wanted to bring to market. This special thermocycler would offer 96 individually controlled wells for greater flexibility and precision in DNA amplification and sequencing. Ascential provided full-scale development and contract manufacturing support, helping reduce development time while enabling a first-to-market platform designed for high performance and scalability.
The Challenge
DNA amplification and sequencing workflows were limited by existing thermocyclers, which lacked the flexibility and precision to control individual reactions in parallel.
The client had a vision for a real-time thermocycler that could independently control each of 96 wells, creating a more flexible platform for genomic research and diagnostics. To bring that complex concept to market, they needed a partner with the engineering, automation, and manufacturing expertise to support development from concept through commercialization. Their goals were clear:
Enable Precise Individual Reaction Control
Support precise control across all 96 wells to improve DNA amplification performance.
Reduce Development Time
Apply Design for Manufacturability and automation to accelerate development and reduce commercialization risk.
Move from Concept to Commercial Manufacturing
Create a production-ready platform that could support quality, performance, and future scale.
Integrate Real-Time Data and Feedback
Incorporate advanced real-time data collection and feedback systems to improve thermocycler performance.
Ascential's Solution
Ascential partnered with the client to provide full-scale development and contract manufacturing support, from concept refinement through commercialization.
The platform required precise thermal management, optics, software, and manufacturing expertise to enable independent control across 96 wells. Ascential supported the development of the individually controlled well architecture and integrated advanced real-time data collection and feedback systems to improve system performance.
By applying Design for Manufacturability, automation, and flexible production processes, Ascential helped overcome the precision manufacturing challenges of bringing a novel thermocycler platform to market. Ascential’s contract manufacturing capabilities supported the transition from development to commercial production while helping reduce development time and improve speed to market.
Technical Capabilities Delivered
The platform brought together multiple technical disciplines required for a complex real-time thermocycler system:
| Capability | What Ascential Built |
|---|---|
| Design for Manufacturability | Development support focused on manufacturability, commercialization, and reduced development time |
| Contract Manufacturing | Full-scale development and manufacturing support from concept to commercialization |
| Thermal Management | Support for precise control across 96 individually controlled wells |
| Optics | Integration support for real-time system performance and data collection |
| Software | Advanced real-time data collection and feedback systems |
| Automation | Flexible production processes to support performance, scalability, and speed to market |
Key Results
- 30% reduction in development time through Design for Manufacturability and automation
- First-to-market real-time thermocycler offering individually controlled wells
- Improved DNA amplification performance metrics by enabling precise control across all 96 wells
- Advanced real-time data collection and feedback systems integrated to improve thermocycler performance
Why It Matters
Genomic research and diagnostics depend on tools that can deliver precision, flexibility, and reliable performance. By enabling independent control across 96 wells, this real-time thermocycler platform gives users greater control over DNA amplification workflows and supports a new level of flexibility in genetic analysis.
For the client, Ascential’s involvement helped reduce development time, address precision manufacturing challenges, and move a novel platform from concept to commercialization. For the market, the result is a first-to-market system designed to advance real-time DNA amplification and sequencing.
Turn Complex Life Sciences Innovation into Commercial Reality
Ascential can help accelerate development, improve manufacturability, and scale production for your next life sciences instrument. Let’s bring your product to market faster.
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